Archive for July, 2008

First report of ambiguous genitalia in diabetic fetopathy

July 30, 2008

A recently published article in Journal of Medical Case Reports describes the case of an infant born to a 19-year-old Thai woman with familial history of diabetes mellitus, which showed evidence of diabetic fetopathy with classic facial malformation and ambiguous genitalia. Although maternal diabetes is known to increase the risk of congenital malformations, this is the first reported case of ambiguous genitalia.

The infant died shortly after birth; the autopsy showed multiple facial anomalies including a prominent forehead, an absent nose, absent bilateral ears and a median cleft lip and palate. The most unusual finding was bilateral adrenal hyperplasia with ambiguous external genitalia, with clitoral hypertrophy and hyperpigmentation. Other anomalies found included preaxial polydactyly of the right hand, accessory spleens and a single umbilical artery.

Chromosomal examination revealed the infant was female, (46, XX) with virilization of female external genitalia. The uterus and both ovaries were in the normal anatomical position.

Have you seen any unusual complications arising from gestational diabetes? Share your experience by posting a comment on this case report, or submit a case report

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Web 2.0 technologies in healthcare

July 29, 2008

A new article from the NHS Resource Centre, ‘Web 2.0 technologies in healthcare‘, discusses what patients, doctors and policy makers are doing with collaborative and multi-media technologies.

Cases Journal is cited as an example of how Web 2.0 technologies are changing the way that medical and scientific knowledge is disseminated. The article includes views from Richard Smith, Editor-in-Chief, on why doctors have been slow to connect in online communities and collaborative tools, compared to patients. PatientsLikeMe is an example of a formalised patient network that connects patients with similar treatment experiences, and as the article explains, patients are often very willing to discuss their problems and experiences openly online.

What do you think? Which Web 2.0 networks and collaborations are you involved with, and why? Do you use Facebook? (Don’t forget to become a fan of Cases Journal if so!) Tell us what you and your colleagues’ views are on the future of online communication and collaboration.

Two cases of anaphylactic reaction to ranitidine

July 24, 2008

injection-sxcJournal of Medical Case Reports has just published its second case report on a patient experiencing anaphylactic shock on injection of ranitidine.

The first case report, published in August last year by UK authors, described the case of a patient with acute pancreatitis being treated with ranitidine for gastric discomfort. The patient rapidly lost consciousness and went into cardio respiratory arrest after treatment with adrenaline, hydrocortisone and high flow oxygen. The patient was successfully resuscitated, and recovered after three days in the ICU.

The new case report, from Antonio Oliva et al, the patient received routine ranitidine administration 24 hours after transurethral resection of the prostate. Within minutes the patient developed wheezing, dyspnea and hypotension and lost consciousness. Despite intensive attempts, the patient could not be resuscitated.

Have you seen an anaphylactic reaction to ranitidine? Share your experience by posting a comment on these case reports, or submit a case report describing what happened.


Update 29 July 2008: Read Dr Ghanshyam Palamaner Subash Shantha’s comment on the latest ranitidine reaction case report! On attending to one of his own patients he writes: “Only on reading this case report I understand in retrospect that ranitidine could be the culprit in this patient’s death.”

Nominations for best case report now open

July 23, 2008

2008-06_research-awards-badge-3rd-annualNominations are now open for the BioMed Central Research Awards, which will include a prize for the best case report, to be awarded at the ceremony in March 2009.

Any case report published in 2008 in Journal of Medical Case Reports or Cases Journal will be eligible for the award. Case reports will be judged on their originality and significance to clinical practice, and the winning authors will receive a $2000 prize. Cases from any area of medicine will be considered.

Nominate a case report by filling in the simple online form.

If you haven’t yet published a case report, submit today to have a chance of winning the award.

The first award for best case report was given to Dr Phuong Mai, for her case report A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report.

Watch Dr Mai’s acceptance speech on BioMed Central’s YouTube channel.

Do we have to understand every sentence?

July 18, 2008

A new editorial from Richard Smith, Editor-in-Chief of Cases Journal, explains the journal’s position on the thorny issue of standards of English in published case reports.

All articles in Journal of Medical Case Reports, Cases Journal’s more selective sister publication, are copyedited before they appear on the journal website. The journal also has a rigorous peer review process that ensures that the accepted articles are in the best possible shape. JMCR’s case reports are of broad interest across medicine and need to be unambiguously understood.

However, Cases Journal has a bias to publish, accepting case reports on any patient, provided that the case is authentic, ethical, includes all essential information, and is understandable. Dr Smith’s editorial elaborates to explain how a case report needs only to be 90% understandable to be accepted. Authors are encouraged to clarify any ambiguities by posting a comment on the published article.

Cases Journal aims to be inclusive. Having English as a second or third language shouldn’t be a barrier to publication. We ask authors to get their article into as good a shape as possible before peer review, but if the reviewer deems the case report to be understandable (and it meets our other criteria) it will be published.

We encourage you as readers to post a comment on any article that you think has ambiguities, or simply if you would like to know more – we hope that publication becomes the start of a dialogue between readers and authors.

A figure is worth a thousand words

July 17, 2008

You asked for more figures and we listened! Authors are now invited to submit up to 10 accompanying figures with their case reports. Of course, all of our images are open access – the images can be reused, provided they are cited correctly. If you have clinical images you would like to share through publishing a case report then visit our instructions for authors to find out more.

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Isolated loss of inferior pubic ramus – our most accessed case report

July 11, 2008

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This month’s most-read case report, ‘Isolated loss of inferior pubic ramus: a case report’, by Aly Saber at the Port Faoud General Hospital in Egypt, has been downloaded over 1600 times in the past 30 days.

The article reports the case of a 35-year-old woman presenting with pain in the left hip joint with no history of trauma. X-rays, and CT and MRI scans showed isolated loss of the left inferior pubic ramus, with thinning of the superior ramus.

Read the full report online.

Open access publication brings your case reports to a worldwide audience – articles are downloaded over 60,000 times each month.

Submit today to share your case report with our readers.

Ketamine use linked to cystitis

July 1, 2008

A newly-published article in Journal of Medical Case Reports describes the case of a 20-year-old man who had 180px-ketamine_10ml_bottlesuffered from urinary frequency, nocturia, urgency, suprapubic discomfort during micturition and episodes of severe haematuria for seven months. The symptoms had started shortly after he began weekly use of ketamine, a dissociative anaesthetic increasingly used as a recreational drug by young adults. Antibiotics and anticholinergics had not improved the symptoms.

Ketamine-associated cystitis has been reported among daily users of ketamine, but this is the first report in a patient who used the drug less frequently.

Read the full report for more information, including details of the previous cases of ketamine-associated cystitis.